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                            October 13, 2020

       Marcio Souza
       Chief Executive Officer
       Praxis Precision Medicines, Inc.
       One Broadway, 16th Floor
       Cambridge, MA 02142

                                                        Re: Praxis Precision
Medicines, Inc.
                                                            Amendment No. 1 to
Registration Statement on Form S-1
                                                            Filed October 9,
2020
                                                            File No. 333-249074

       Dear Mr. Souza:

              We have reviewed your amended registration statement and have the
following
       comment. In our comment, we may ask you to provide us with information
so we may better
       understand your disclosure.

              Please respond to this letter by amending your registration
statement and providing the
       requested information. If you do not believe our comment applies to your
facts and
       circumstances or do not believe an amendment is appropriate, please tell
us why in your
       response.

              After reviewing any amendment to your registration statement and
the information you
       provide in response to the comment, we may have additional comments.

       Amendment 1 to Registration Statement on Form S-1

       Exhibits

   1.                                                   Please have counsel
file a revised Exhibit 5.1 opinion that covers all securities being
                                                        registered. In this
regard, we note you are registering 8,510,000 common shares and that
                                                        your legal opinion
covers 8,455,882 common shares.
 Marcio Souza
Praxis Precision Medicines, Inc.
October 13, 2020
Page 2

       You may contact Gary Newberry at 202-551-3761 or Kate Tillan at
202-551-3604 if you
have questions regarding comments on the financial statements and related
matters. Please
contact Courtney Lindsay at 202-551-7237 or Christine Westbrook at 202-551-5019
with any
other questions.



                                                        Sincerely,
FirstName LastNameMarcio Souza
                                                        Division of Corporation
Finance
Comapany NamePraxis Precision Medicines, Inc.
                                                        Office of Life Sciences
October 13, 2020 Page 2
cc:       William D. Collins, Esq.
FirstName LastName